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Nanoparticle-loaded protein-polymer nanodroplets for improved stability and conversion efficiency in ultrasound imaging and drug delivery

Abstract:

We have developed a new formulation of volatile nanodroplets, stabilised by a protein and polymer coating. The nanodroplets are prepared from hydrophobic perfluoropentane (PFP) and coated with human serum albumin and polyethylene glycol modified N-hydrosuccinimide conjugated in dichloromethane using an oil-in-water emulsification method. The resulting nanodroplets have an average diameter of 344 nm and are stable at 37oC for several days. These properties offer advantages both for storage of ...

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Department:
Engineering Science
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Department:
Engineering Science
Role:
Principal Investigator, Creator
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Department:
Engineering Science
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Creator
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Department:
Engineering Science
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Creator, Contributor
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Department:
Engineering Science
Role:
Creator, Contributor
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Publisher:
University of Oxford
Publication date:
2015
DOI:
Data collected:
2015-07-15 - 2015-07-15
Language:
English
Keywords:
Format:
Digital
Documentation:
These data were created on 15th July of 2015 for the paper to be published in Advanced Materials.

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