Nanoparticle‐Loaded Protein–Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery

Journal article

A new formulation of volatile nanodroplets stabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

Authors: Lee, J; Carugo, D; Crake, C; Owen, J; De Saint Victor, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley
• Journal: Advanced Materials
• Volume: 27
• Issue: 37
• Pages: 5484-5492
• Publication date: 2015-08-11
• DOI: 10.1002/adma.201502022
• EISSN: 1521-4095
• ISSN: 0935-9648
• Pmid: 26265592
• Language: English
• Keywords: Cell Survival; Research Support, Non-U.S. Gov't; Drug Carriers; Serum Albumin; Ultrasonography; Antineoplastic Agents; Drug Delivery Systems; Antineoplastic Agents, Phytogenic; Oleic Acid; Quaternary Ammonium Compounds; Humans; Ferric Compounds; Journal Article; MCF-7 Cells; Fluorocarbons; Drug Liberation; Magnetite Nanoparticles; SBTMR; Polyethylene Glycols; Paclitaxel; Equipment Design