Thesis
Investigating the regenerative potential of the neonatal mouse heart
- Abstract:
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After myocardial infarction (MI), the adult human heart is unable to regenerate lost tissue, leading to scarring, pathological remodelling and eventual progression to heart failure. There is currently no known “cure” other than the limited option of heart transplantation. The study of animal models that can intrinsically regenerate their heart offers potential insights into how to therapeutically target tissue restoration. Whilst regeneration is widely accepted for some amphibians and species...
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- Files:
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(Preview, Dissemination version, pdf, 10.8MB, Terms of use)
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Authors
Contributors
+ Riley, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0002-9862-7332
+ Swietach, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0002-9945-9473
+ Carr, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
- ORCID:
- 0000-0003-0102-5261
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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2420724
- Local pid:
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pubs:2420724
- Deposit date:
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2026-04-27
- ARK identifier:
Terms of use
- Copyright holder:
- Mala Gunadasa-Rohling
- Copyright date:
- 2024
- Notes:
- Magnetic resonance imaging of the regenerating neonatal mouse heart is derived from this thesis.
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