Journal article
Magnetic resonance imaging of the regenerating neonatal mouse heart
- Abstract:
- After myocardial infarction (MI) the human heart is unable to regenerate lost tissue, leading to scarring, pathological remodeling and progression to heart failure. The study of animal models that can intrinsically regenerate their heart, therefore, offers therapeutic insight into targeting tissue restoration. In 2011, the first evidence of mammalian heart regeneration was reported by Hesham Sadek, Eric Olson and colleagues1. Following surgical resection of ~15% of the left ventricle apex of a oneday old (P1) neonatal mouse, the heart fully regenerated by 21-days post-injury, whereas if the procedure was repeated one week later on a post-natal day 7 (P7) mouse heart, fibrosis and scarring ensued, recapitulating the adult wound-healing response. The mechanism of regeneration observed involved proliferation of resident cardiomyocytes, analogous to that described in the adult zebrafish heart2. Since the original study others have described neonatal myocardial regeneration after alternative insults, such as MI3. However, there is also controversy surrounding the extent of heart regeneration during the first weeks of life, whereby it was reported regeneration did not occur in the P1 heart and was replaced by long-term fibrosis (180 days) with extensive cardiac remodelling4.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 224.2KB, Terms of use)
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- Publisher copy:
- 10.1161/CIRCULATIONAHA.118.036086
Authors
+ British Heart Foundation
More from this funder
- Funding agency for:
- Gunadasa-Rohling, M
- Schneider, J
- Riley, P
- Grant:
- RM/13/3/30159
- RM/13/3/30159
- RM/13/3/30159
- Publisher:
- American Heart Association
- Journal:
- Circulation More from this journal
- Volume:
- 138
- Issue:
- 21
- Pages:
- 2439–2441
- Publication date:
- 2018-11-19
- Acceptance date:
- 2018-08-27
- DOI:
- EISSN:
-
1524-4539
- ISSN:
-
0009-7322
- Pubs id:
-
pubs:926045
- UUID:
-
uuid:dc97e670-3ef2-469f-8600-f5e0d7154a3d
- Local pid:
-
pubs:926045
- Source identifiers:
-
926045
- Deposit date:
-
2018-10-10
Terms of use
- Copyright holder:
- Gunadasa-Rohling, Masters, and Maguire et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited
- Licence:
- CC Attribution (CC BY)
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