Robustness of evolutionary and glassy systems

Thesis

Systems which take in a sequence-based input to produce a nontrivial output are ubiquitous across science. One key property of such maps is the robustness of the output upon random changes of the inputs. Interestingly, recent work on genotype-phenotype maps in biology has shown that the robustness, defined as the probability that a point mutation to the genotype does not change the phenotypic output, is typically exponentially higher than a null expectation based on a random input-output ...

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Authors: Mohanty, V

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: statistical physics; maximum entropy; evolution; input-output maps; robustness; spin glass; genotype-phenotype maps; graph theory
• Subjects: Spin glasses; Evolution; Statistical physics; Genotype-phenotype maps; Graph theory