- Abstract:
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This thesis is divided into two parts:
Part 1
(i) The Synthesis of a Biologically Active Analogue of Antibiotic A-32390A
Methodology for the preparation of vinyl formamides from thiooximes has been developed for use with α-carboxy systems and successfully applied to the synthesis of (2S, 3S)-2,3-di-[hydroxybutane]-1,4-di-[2-isocyano-3-methyl-but-2-enoate], a vinyl isonitrile that is a biologically active analogue of the natural product, antibiotic A-...
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- Publication date:
- 1994
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- URN:
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uuid:f269cecc-8b50-4596-8235-e1b01b9bb134
- Local pid:
- td:603835731
- Language:
- English
- Subjects:
- Copyright holder:
- Smith, Marie-Louise
- Copyright date:
- 1994
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
Thesis
The synthesis of (+/-)- trichoviridin, WF-10129 and a biologically active analogue of antibiotic A-32390A
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