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Thesis

Fatty acids and the regulation of pyruvate dehydrogenase interconversion

Abstract:

This thesis presents evidence for a novel mechanism of regulation of pyruvate dehydrogenase (PDH) kinase by fatty acids and also results of a study of muscle triacylglycerol concentration. In animals regulation of PDH complex activity is central to the selection of respiratory fuels and to the conservation of glucose during carbohydrate deprivation. The principal means of regulation of PDH complex is interconversion of phosphorylated (inactive) and dephosphorylated (active) forms effected...

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Institution:
University of Oxford
Department:
Nuffield Dept. of Clinical Biochemistry
Role:
Author
Publication date:
1997
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:d05910c0-f7a1-4363-ac2c-a9a1eb857964
Local pid:
td:603835424
Source identifiers:
603835424
Deposit date:
2013-10-21

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