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Radiation damage in protein crystallography: susceptibility study

Abstract:

Protein structure models obtained from X-ray crystallography are subject to radiation damage. The resulting specific alterations to protein structures can be mistaken for biological features, or may obscure actual protein mechanisms, leading to misidentification or obscuration of biological insight. The radiation chemistry behind this site-specific damage is not well understood.

Radiation damage processes progress in proportion to the dose absorbed by the crystal in the diffraction ...

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Institution:
University of Oxford
Research group:
Garman Group
Oxford college:
St Hilda's College
Department:
Mathematical,Physical & Life Sciences Division - Other - Systems Biology Doctoral Training Centre
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:be55baee-19b7-4a34-8694-fb9c3606a19c
Local pid:
ora:11594

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