Intracranial aneurysm disease: novel modelling of inception and the microstructural adaption of collagen fabric

Thesis

An intracranial aneurysm (IA) is a balloon-like focal lesion on the cerebral arterial wall. IAs are poorly understood, but are commonly considered to be a disease caused by multiple factors. Current interventional treatments are accompanied with risks. Given the low incidence of rupture, it would be ideal to only treat aneurysms identified with rupture risk. Numerical models of aneurysm development may provide insight into the disease mechanisms, and contribute to the prediction of disease...

Expand abstract

Authors: Chen, H

• Publication date: 2014
• DOI: 10.5287/ora-kz5g5enr5
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: cerebral aneurysm; intracranial aneurysm; collagen; haemodynamics; stress; mathematical modelling; strain; elastin
• Subjects: Mathematical modeling (engineering); Medical Engineering; Biomedical engineering