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Thesis

Modelling and simulation of phenotypic variability in cardiac tissue and application to stem cell-derived cardiomyocytes

Abstract:

Prediction of the safety of a novel pharmaceutical compound at the earliest possible stage of development is of great importance for drug discovery. Cardiac side-effects are a particular cause for concern, with several drugs such as Terfenadine and Cisapride having being withdrawn from the market due to adverse events. Investigation of the properties of novel compounds can be facilitated by the use of in silico models, which can provide a high-throughput and low-cost method of translating ...

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Division:
MPLS
Department:
Computer Science
Role:
Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Bowler, L
Grant:
EP/F500394/1
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:a138d837-be95-487e-87e5-e1cf4769e9a4
Deposit date:
2019-06-26

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