Thesis icon

Thesis

Modelling and simulation of phenotypic variability in cardiac tissue and application to stem cell-derived cardiomyocytes

Abstract:

Prediction of the safety of a novel pharmaceutical compound at the earliest possible stage of development is of great importance for drug discovery. Cardiac side-effects are a particular cause for concern, with several drugs such as Terfenadine and Cisapride having being withdrawn from the market due to adverse events. Investigation of the properties of novel compounds can be facilitated by the use of in silico models, which can provide a high-throughput and low-cost method of translating ...

Expand abstract

Actions


Access Document


Files:

Authors


Contributors

Role:
Supervisor
Role:
Supervisor
More from this funder
Grant:
EP/F500394/1
Funding agency for:
Louise Bowler
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP