Thesis
Biomechanics of intestinal crypt morphogenesis
- Abstract:
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The intestinal epithelium exhibits remarkable rates of self-renewal to protect the small intestine and colon from damage during digestion and facilitate nutrient absorption. This monolayer of epithelial cells is maintained by the crypts of Liehberkühn, test-tube-shaped glands that are robust in morphology and structure, undergoing significantly large deformations, despite comprising a heterogeneous composition of cells with varying proliferative capacities and mechanical properties. While ...
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(Preview, pdf, 15.5MB, Terms of use)
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Authors
Contributors
+ Byrne, H
- Department:
- Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford
- Role:
- Supervisor
+ Maini, P
- Department:
- Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford
- Role:
- Supervisor
+ Moulton, D
- Department:
- Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford
- Role:
- Supervisor
+ Simmons, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Role:
- Supervisor
+ Goriely, A
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Mathematical Institute
- Role:
- Examiner
+ Cancer Research UK
More from this funder
- Funding agency for:
- Almet, A
- Grant:
- Oxford Centre Prize DPhil Studentship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
-
uuid:491cb9ee-8517-4f93-a178-0a5e2e49f841
- Deposit date:
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2019-12-18
- ARK identifier:
Terms of use
- Copyright holder:
- Almet, A
- Copyright date:
- 2019
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