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Thesis

Neuronal nitric oxide synthase-CAPON regulation of cardiac sympathetic activity in the development of hypertension

Abstract:

The studies presented in this thesis were undertaken to investigate the cellular and molecular mechanisms responsible for sympathetic hyperactivity that is observed in the Spontaneous Hypertensive Rat (SHR) and whether these abnormalities arise even before the onset of hypertension. Moreover, selected molecular candidates related to oxidative state in cardiac autonomic signalling have been explored for their potential therapeutic effects.

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Institution:
University of Oxford
Research group:
David Paterson
Oxford college:
Merton College
Department:
Medical Sciences Division - Sherrington Building,Le Gros Clark Building

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1204dec9-9f09-458d-b361-c8d14589fcd1
Local pid:
ora:11480
Language:
English
Keywords:
Subjects:

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