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Thesis

Cavitation-enhanced tumour-targeting virotherapy by ultrasound

Abstract:

Systemic administration of adenovirus type 5 (Ad5) vectors for the treatment of cancer is limited by poor circulation kinetics and inefficient uptake from the bloodstream into tumours. This study reports a novel method for linkage of highly-PEGylated gold nanoparticles (AuPEG) to Ad5 by a single reduction cleavable bond. The resulting ‘dandelion’ structure provides very effective steric shielding with only minimal and reversible modification of the Ad5 capsid. This ablates in vitro cell in...

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Institution:
University of Oxford
Research group:
Biomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory
Oxford college:
St John's College
Department:
Mathematical,Physical & Life Sciences Division - Engineering Science

Contributors

Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Steven Mo
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:1104179a-ff58-4ff7-a637-8247a80399ec
Local pid:
ora:8325

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