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Substrate recognition by the proteasome

Abstract:

The ubiquitin proteasome system targets proteins to the proteasome where they are degraded. Substrate recognition and processing prior to degradation take place at the 19S regulatory particle of the proteasome. A polyubiquitin chain, linked through isopeptide bonds formed between the C-terminal G76 and K48, is the signal responsible for delivery to the proteasome. Because chains linked via any of the seven lysine residues of ubiquitin exist in vivo and encode signals unrelated to protein degr...

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Institution:
University of Oxford
Research group:
Laboratory of Molecular Biophysics
Oxford college:
Linacre College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Role:
Supervisor
Role:
Supervisor
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Funding agency for:
Jonas Boehringer
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:036151d9-5062-4ffe-a1ef-a58e1b020680
Local pid:
ora:5368

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