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Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring

Abstract:

Background: Populations of East Africa including Sudan, exhibit some of the highest indices of genetic diversity in the continent and worldwide. The current study aims to address the possible impact of population structure and population stratification on the outcome of case-control association-analysis of malaria candidate-genes in different Sudanese populations, where the pronounced genetic heterogeneity becomes a source of concern for the potential effect on the studies outcome. Methods: A...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1475-2875-9-119

Authors


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Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
Role:
Author
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Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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MalariaGEN Consortium More from this funder
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
9
Article number:
119
Publication date:
2010-05-01
DOI:
ISSN:
1475-2875
Language:
English
Keywords:
Subjects:
UUID:
uuid:01c0340b-8510-4f16-9add-301f5d575255
Local pid:
ora:3830
Deposit date:
2010-06-01

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