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Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring

Abstract:

Background: Populations of East Africa including Sudan, exhibit some of the highest indices of genetic diversity in the continent and worldwide. The current study aims to address the possible impact of population structure and population stratification on the outcome of case-control association-analysis of malaria candidate-genes in different Sudanese populations, where the pronounced genetic heterogeneity becomes a source of concern for the potential effect on the studies outcome. Methods: A...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1475-2875-9-119

Authors


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Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
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Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
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Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
University of Khartoum, Sudan
Department:
Department of Molecular Biology,Institute of Endemic Diseases
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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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MalariaGEN Consortium More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
Malaria Journal Journal website
Volume:
9
Pages:
Article: 119
Publication date:
2010-05-05
DOI:
ISSN:
1475-2875
URN:
uuid:01c0340b-8510-4f16-9add-301f5d575255
Local pid:
ora:3830

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