Thesis
Identifying genes involved in beta cell dysfunction using high-throughput genetic and genomic approaches
- Abstract:
-
Genome-wide association studies have identified >400 signals which are robustly associated with type 2 diabetes (T2D) risk, a large proportion of which are involved in pancreatic beta cell dysfunction. A major barrier to translational insight however is uncertainty over the genes through which they exert their effect. The aim of this thesis was to perform the first genome-wide pooled CRISPR screen in human beta cells and use a high-throughput and unbiased approach to identify candidate cau...
Expand abstract
Actions
Authors
+ Radcliffe Department of Medicine
More from this funder
- Funder identifier:
- http://dx.doi.org/10.13039/501100000769
- Programme:
- Radcliffe Department of Medicine Scholarship
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2020-10-10
Terms of use
- Copyright holder:
- Grotz, A
- Copyright date:
- 2020
If you are the owner of this record, you can report an update to it here: Report update to this record