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Thesis

Establishment and maintenance of the DNA methylation pattern in the human alpha-globin cluster

Abstract:

DNA methylation is an epigenetic modification that plays an important role in development and differentiation. The patterns of DNA methylation are largely established in early embryogenesis and maintained during development. Abnormal DNA methylation patterns have been associated with many human diseases, including cancer. Despite its importance, little is currently known about the mechanisms that determine DNA methylation patterns throughout the genome. To shed light on the molecular mecha...

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Molecular Haematology Unit (MHU), Weatherall Institute of Molecular Medicine (WIMM)
Oxford college:
University College
Role:
Author

Contributors

Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Supervisor

More from this funder
Funding agency for:
Gaentzsch, R

Publication date:
2013
DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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