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Thesis

Biochemical studies on muscarinic cholinergic receptors

Abstract:

A novel solubilising agent (0.l% sodium cholate—lM NaCl) has been developed which will solubilise 10—30% of muscarinic cholinergic receptors from bovine caudate nucleus. Using the muscarinic antagonist quinuclidinyl benzilate (QNB), a single saturable binding component was found with an equilibrium constant of ZOOpM, approximately 10—fold higher than the membrane receptor and 4—fold higher than the ratio k-l/kl determined kinetically in the soluble material. Th...

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Institution:
University of Oxford
Oxford college:
Lincoln College
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:feb8f219-8bd9-4140-94b8-1d6fc16e2ad2
Deposit date:
2016-06-14

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