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Effects of catechol-o-methyltransferase on reinforcement learning and mesolimbic dopamine transmission

Abstract:

The enzyme catechol-O-methyltransferase (COMT) plays an important role in the breakdown of dopamine in prefrontal cortex (PFC), but relatively little is known about its effects on nucleus accumbens (NAc) dopamine function. In this study, a transgenic mouse model of the Val158Met polymorphism found in the human COMT gene was used (a) to investigate the effects of COMT on associative learning, a process dependent on NAc dopamine, and (b) to relate this to potential changes in phasic dopamine...

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Division:
MSD
Department:
Psychiatry
Department:
University of Oxford
Role:
Author

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Supervisor
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Supervisor
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Name:
Medical Research Council
Grant:
1175705
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:fca24ceb-e1e4-4033-b684-76ad6ae08290
Deposit date:
2016-09-13

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