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Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles

Abstract:

Vascular smooth muscle contraction is suppressed by feedback dilation mediated by the endothelium. In skeletal muscle arterioles, this feedback can be activated by Ca2+ signals passing from smooth muscle through gap junctions to endothelial cells, which protrude through holes in the internal elastic lamina to make contact with vascular smooth muscle cells. Although hypothetically either Ca2+ ions or inositol trisphosphate (IP3) may provide the intercellular signal, it is generally thought tha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/scisignal.aal3806

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Institution:
University of Oxford
Oxford college:
Magdalen College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
More from this funder
Name:
British Heart Foundation
Funding agency for:
Dora, KA
Grant:
Senior Basic Science Research Fellow
RE/13/1/30181
More from this funder
Name:
Royal Society
Funding agency for:
Garland, CJ
Grant:
Wolfson Merit Award
More from this funder
Name:
Wellcome Trust
Grant:
089815/Z/09/Z
Publisher:
American Association for the Advancement of Science
Journal:
Science Signaling More from this journal
Volume:
10
Issue:
486
Article number:
eaal380
Publication date:
2017-07-01
Acceptance date:
2017-06-15
DOI:
EISSN:
1937-9145
ISSN:
1945-0877
Pubs id:
pubs:701743
UUID:
uuid:fc4aec47-b582-456f-8141-51bac37b4dbb
Local pid:
pubs:701743
Source identifiers:
701743
Deposit date:
2017-07-05

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