Thesis
Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach
- Abstract:
-
The circadian clock is an evolutionarily conserved mechanism which synchronizes physiology and behaviour across a 24-hour cycle. Rodent models have shown that hepatic lipid and glucose metabolism are under tight circadian control however translational human studies are lacking. Metabolic dysfunction associated steatotic liver disease (MASLD) is the most common liver disease worldwide and is associated with a high global burden of liver- and cardiovascular-related morbidity and mortality. U...
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Authors
Contributors
+ Tomlinson, J
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
+ Hodson, L
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
- ORCID:
- 0000-0002-2648-6526
+ Ray, D
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
- ORCID:
- 0000-0002-4739-6773
+ Rosetrees Trust
More from this funder
- Funder identifier:
- https://ror.org/04e3zg361
- Programme:
- Seedcorn Grant
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Programme:
- Clinical Research Training Fellowship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Pubs id:
-
2083768
- Local pid:
-
pubs:2083768
- Deposit date:
-
2025-01-31
- ARK identifier:
Terms of use
- Copyright holder:
- Marjot, T
- Copyright date:
- 2023
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