Thesis
Development of chemogenetic methodology to investigate cortical mechanisms of cognition
- Abstract:
-
DREADDs (designer receptors exclusively activated by designer drugs) are virally mediated engineered muscarinic receptors that no longer bind their endogenous ligand acetylcholine but instead bind the clozapine metabolite, clozapine-N-oxide (CNO). These receptors are a very useful research tool for deconstructing behaviour due to their promoter-driven cell- specificity and potential spatial resolution, the low invasiveness associated with their use, reversibility and the temporal resolutio...
Expand abstract
Actions
Access Document
- Files:
-
-
(Preview, Dissemination version, pdf, 40.6MB, Terms of use)
-
Authors
Contributors
+ Sharp, T
- Role:
- Supervisor
- ORCID:
- 0000-0001-7434-9713
+ Frisch Herrik, K
- Role:
- Supervisor
+ Bannerman, D
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Pubs id:
-
2360227
- Local pid:
-
pubs:2360227
- Deposit date:
-
2020-07-02
- ARK identifier:
Terms of use
- Copyright holder:
- Rotariu, SM
- Copyright date:
- 2019
If you are the owner of this record, you can report an update to it here: Report update to this record