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Thesis

Analysis of human non-canonical 3’end formation signals

Abstract:

Cleavage and polyadenylation are essential pre-mRNA processing reactions maturing the 3’end of almost all protein encoding eukaryotic mRNAs. Analysis of the sequences required for cleavage and polyadenylation in the human melanocortin 4 receptor (MC4R) and the human transcription factors JUNB and JUND pre-mRNAs revealed that, at least for some mammalian genes, 3’end processing of the primary transcript is independent of previously described auxiliary sequence elements located upstream or down...

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Institution:
University of Oxford
Research group:
Dr Andre Furger
Oxford college:
Corpus Christi College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Nuno Miguel Da Rocha Oliveira Nunes
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:f77c04f1-7530-442d-8654-81ccb6d0e362
Local pid:
ora:6659

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