The evolution and development of left/right asymmetry in the Lophotrochozoa

Thesis

Left/right (L/R) asymmetries, differences in morphology between the otherwise mirrored left- and right-hand sides of the body, are found in animals across the Bilateria. For many years it was thought that the mechanisms for establishment of these asymmetries had evolved separately in the three superphyla that constitute the Bilateria, but the discovery in 2009 that the TGF-beta ligand Nodal shares a conserved role in the Deuterostomia and Lophotrochozoa has re-ignited debate and interest i...

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Authors: Kenny, NJ

• Publication date: 2014
• DOI: 10.5287/ora-da4xnwmzj
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: TGF; Asymmetry; Nodal; Lophotrochozoa
• Subjects: Genetics (life sciences); Development (zoology); Evolution (zoology); Biology; Bioinformatics (biochemistry)