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The genetics of amyotrophic lateral sclerosis

Abstract:

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised clinically by rapidly progressive paralysis leading ultimately to death from respiratory failure. There is no cure for ALS and no definitive explanation for the onset and rapid progression of motor neuron degeneration. Genetics is a known risk factor for a portion of familial cases. However, the role of genetics in the commoner sporadic form of the disease is poorly understood, although numerous genes have ...

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Institution:
University of Oxford
Oxford college:
Keble College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Publication date:
2009
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:f68f15c2-2875-46ba-bf25-8324c1dead91
Local pid:
ora:3053

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