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Autophagy is indispensable for normal maturation and function of macrophages and neutrophils

Abstract:

Macrophages and neutrophils are vital cells of the immune system, performing crucial innate functions and bridging innate and adaptive immunity. However, inappropriate activation or poor resolution of responses results in chronic inflammatory and autoimmune conditions due to accumulation of myeloid cells and uncontrolled cytokine production, as is commonly seen in the aging immune system. It is not clear what is required to maintain healthy myeloid cells throughout life or what links infla...

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Institution:
University of Oxford
Oxford college:
University College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of

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Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:f68e5f62-2e89-40be-abd8-816145cc1579
Local pid:
ora:8377

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