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Thesis

The role of p53 in hypoxia-induced apoptosis

Abstract:

Tumour hypoxia is associated with resistance to therapy, increased aggressiveness and a poor patient prognosis. The tumour suppressor p53 causes apoptosis in response to hypoxia and therefore hypoxic tumours select for the loss of p53.

In this work was we have investigated the post-translational modifications and binding partners of p53 in hypoxia. Furthermore, we investigated the p53-dependent gene expression changes in hypoxia.

We have shown that p53 is stabilised and phosp...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Oxford college:
Wolfson College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Publication date:
2010
Type of award:
MSc
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:f64d1a96-9657-4426-b94f-b3f94fe25823
Local pid:
ora:6349
Deposit date:
2012-07-10

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