Thesis icon

Thesis

Characterisation of pitch: an early onset model of sensorineural deafness

Abstract:

At MRC Harwell n-ethyl-n-nitrosourea (ENU) mutagenesis coupled with auditory phenotyping is utilised to generate new mouse models of hearing loss. This approach identified pitch, an autosomal recessive model of early-onset, sensorineural deafness (+90dB). Mapping studies identified a 1.6Mb critical region comprising a novel deafness locus on chromosome 9 and prioritised candidate gene sequencing identified a coding mutation in Neuroplastin (Nptn).

This th...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
MRC Harwell
Oxford college:
Wolfson College
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
More from this funder
Name:
Medical Research Council
Funding agency for:
Carrott, L
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:f6488b47-ef6e-42db-9bb2-551ebfe9bc21
Local pid:
ora:11316
Deposit date:
2015-04-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP