Thesis icon

Thesis

Targeting host cell processing glucosidase activity as a potential strategy for reducing viral replication

Abstract:

The anti-viral efficacy of N-butyl-deoxynojirimycin (NB-DNJ, Miglustat, Zavesca) against a broad spectrum of viruses including bovine viral diarrhoea virus (BVDV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is attributed to the disruption of viral envelope glycoprotein formation through the inhibition of the host ER alpha(α)-glucosidase activity. The DNJ-derived compound, N-(6'-4"-azido-2"-nitrophenylamino) hexyl-1-deoxynojirimycin (NAP-DNJ) is a more potent ER α-glucos...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Lee, M
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:f5f32e9f-fe97-44d5-8d24-5c61a109178a
Deposit date:
2017-11-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP