Thesis icon

Thesis

Targeting host cell processing glucosidase activity as a potential strategy for reducing viral replication

Abstract:

The anti-viral efficacy of N-butyl-deoxynojirimycin (NB-DNJ, Miglustat, Zavesca) against a broad spectrum of viruses including bovine viral diarrhoea virus (BVDV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is attributed to the disruption of viral envelope glycoprotein formation through the inhibition of the host ER alpha(α)-glucosidase activity. The DNJ-derived compound, N-(6'-4"-azido-2"-nitrophenylamino) hexyl-1-deoxynojirimycin (NAP-DNJ) is a more potent ER α-glucos...

Expand abstract

Actions


Access Document


Files:

Authors


Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Marvin J.-R. Lee
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP