- Abstract:
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The anti-viral efficacy of N-butyl-deoxynojirimycin (NB-DNJ, Miglustat, Zavesca) against a broad spectrum of viruses including bovine viral diarrhoea virus (BVDV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is attributed to the disruption of viral envelope glycoprotein formation through the inhibition of the host ER alpha(α)-glucosidase activity. The DNJ-derived compound, N-(6'-4"-azido-2"-nitrophenylamino) hexyl-1-deoxynojirimycin (NAP-DNJ) is a more potent ER α-glucos...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2011
Thesis
Targeting host cell processing glucosidase activity as a potential strategy for reducing viral replication
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