Thesis
Metabolic modulation through deletion of hypoxia-inducible factor-1alpha and fumarate hydratase in the heart
- Abstract:
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Hypoxia inducible factor-1α (HIF-1α) plays a critical role in the oxygen homeostasis of all metazoans. HIF-1α is a master transcriptional regulator which coordinates the adaptive response to low oxygen tension. Through activation of a plethora of downstream target genes, HIF-1α facilitates oxygenation by promoting angiogenesis and blood vessel dilation, in addition to modulating metabolic pathways to inhibit oxidative phosphorylation and promote glycolytic energy production. Given the crit...
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- Files:
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(bin, 8.2MB, Terms of use)
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Authors
Contributors
+ Ashrafian, H
- Division:
- MSD
- Department:
- RDM
- Sub department:
- RDM Cardiovascular Medicine
- Role:
- Supervisor
+ Watkins, H
- Division:
- MSD
- Department:
- RDM
- Sub department:
- RDM Cardiovascular Medicine
- Role:
- Supervisor
- Publication date:
- 2015
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:f546ca24-6226-4846-b492-30de26836e94
- Local pid:
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ora:12359
- Deposit date:
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2015-11-27
- ARK identifier:
Terms of use
- Copyright holder:
- Steeples, V
- Copyright date:
- 2015
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