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Thesis

Duchenne muscular dystrophy: RNA-based therapeutics and microRNA biology

Abstract:

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by absence of functional dystrophin protein. This thesis describes investigations into the role of small non-coding RNAs in both DMD pathology, and as potential therapeutic molecules.

MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression and are implicated in wide-ranging cellular processes and pathological conditions. This study has compared differential miRNA expression in proxim...

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Institution:
University of Oxford
Research group:
Wood Lab
Oxford college:
Oriel College
Department:
Medical Sciences Division - Physiology,Anatomy and Genetics,Department of
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:f53ea1f3-92db-4f90-ba95-01f2a56eae8f
Local pid:
ora:7096
Language:
English
Keywords:
Subjects:

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