Thesis
An investigation of the molecular genetics of some disorders of the mitochondrion
- Abstract:
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Mitochondrial DNA is exclusively maternally inherited, and encodes a proportion of the subunits of the electron transport chain. As some of the mitochondrial myopathies show a maternal pattern of inheritance and/or a biochemical defect of respiratory chain components, they could be caused by mutations in the mitochondrial genome. Leber's hereditary optic neuropathy could arise in the same way, as it is maternally inherited.
The main aim of this project was to determine whether mutat...
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(Preview, pdf, 14.8MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:f36f8c19-c897-45e2-b5a2-56878c110c50
- Local pid:
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polonsky:13:2
- Source identifiers:
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601870791
- Deposit date:
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2017-10-05
- ARK identifier:
Terms of use
- Copyright holder:
- Poulton, J; Poulton, Joanna
- Copyright date:
- 1990
- Notes:
- This thesis was digitised thanks to the generosity of Dr Leonard Polonsky
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