Carbonic anhydrase activity and its role in membrane H+-equivalent transport in mammalian ventricular myocytes

Thesis

Carbonic anhydrases (CAs) are fundamental and ubiquitous enzymes that catalyse the reversible hydration of CO₂ to form HCO₃^- and H⁺ ions. Evidence derived from heterologous expression systems has led to the proposal of a novel role for CA in intracellular pH regulation, where its physical and functional coupling to membrane H⁺ -equivalent transport proteins appears to enhance their activity. It has yet to be established whether such a ...

Expand abstract

Authors: Villafuerte, F

• Publication date: 2007
• DOI: 10.5287/ora-ordvmodmp
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Subjects: Carbonic anhydrase; Muscle cells; Biological transport