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Thesis

The role of ATF4 in hypoxia-induced cell death in cancer

Abstract:

Cancer cells survive the harsh oxygen and nutrient deprivation of the tumour microenvironment through the selection of apoptosis-resistant and glycolytic clones (Cairns et al., 2011; Graeber et al., 1996). In particular, the integrated stress response (ISR) has been shown to be pivotal in cancer cell survival in vivo and the resistance of cancer cells to therapy (Harding et al., 2003). In recent years, it has become apparent that increased autophagy is one mechanism by which the...

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Institution:
University of Oxford
Research group:
Harris Group - Growth Factors
Oxford college:
St John's College
Department:
Medical Sciences Division - Medical Oncology

Contributors

Role:
Supervisor
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Funding agency for:
Luke R. G. Pike
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:f32e03f9-0bd2-4dd1-8320-b082b9b2d363
Local pid:
ora:6351

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