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Thesis

Using a multi-omics approach to identify novel targets in multiple myeloma

Abstract:

Multiple myeloma (MM) is an incurable cancer of plasma cells, with an average five-year survival rate of approximately 50%. Over the last two decades, application of MM therapeutics, namely proteasome inhibitors (PI) and immunomodulatory imide drugs (IMiD), have almost doubled median survival time of MM patients. However, most patients will develop drug resistance. Acquired anti-cancer drug resistance remains one of the biggest barriers in the treatment of myeloma. Therefore, identifying n...

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Authors

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Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
Oppermann group
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0001-9658-5354

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
Oppermann group
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Botnar Research Centre
Research group:
Oppermann group
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Supervisor

More from this funder
Funder identifier:
http://dx.doi.org/10.13039/100004330
Funding agency for:
James-Bott, A
Programme:
Systems approaches to biomedical sciences
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Funding agency for:
James-Bott, A
Programme:
Systems approaches to biomedical sciences

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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