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Thesis

Forward genetic and cellular studies of immune regulation: the roles of Carma1, Interleukin-10 and Gimap5

Abstract:

The differentiation and functional specialisation of CD4+ T cells into distinct subsets allows inflammatory responses to be targeted to diverse types of insults. One subset of CD4+ T cells, Foxp3+ regulatory T (Treg) cells, acts to restrain excessive effector T cell responses and can develop in either the thymus or peripheral tissues. Here, a mouse with a germline point mutation in Carma1, an essential component of the signalling cascade linking the...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Research group:
Fiona Powrie lab
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:f2745737-9f3b-4920-971e-961aac451bdf
Local pid:
ora:5111
Deposit date:
2011-03-11

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