- Abstract:
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In March of 2018, the National Kidney Foundation, in collaboration with the US Food and Drug Administration and the European Medicines Agency, sponsored a workshop in which surrogate endpoints other than currently established event‐time endpoints for clinical trials in chronic kidney disease (CKD) were presented and discussed. One such endpoint is a slope‐based parameter describing the rate of decline in the estimated glomerular filtration rate (eGFR) over time. There are a number of challeng...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
-
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(pdf)
-
- Publisher copy:
- 10.1002/sim.8282
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- Publisher:
- Wiley Publisher's website
- Journal:
- Statistics in Medicine Journal website
- Volume:
- 38
- Issue:
- 22
- Pages:
- 4218-4239
- Publication date:
- 2019-07-23
- Acceptance date:
- 2019-05-29
- DOI:
- EISSN:
-
1097-0258
- ISSN:
-
0277-6715
- Pubs id:
-
pubs:1035881
- UUID:
-
uuid:f23e1b05-6d8e-4634-9eb2-a5775f2dc619
- Source identifiers:
-
1035881
- Local pid:
- pubs:1035881
- Language:
- English
- Keywords:
- Copyright holder:
- John Wiley & Sons, Ltd.
- Copyright date:
- 2019
- Rights statement:
- © 2019 John Wiley & Sons, Ltd.
- Notes:
- This is the accepted manuscript version of the article. The publisher's version is available online
Journal article
Mixed‐effects models for slope‐based endpoints in clinical trials of chronic kidney disease
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