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Mixed‐effects models for slope‐based endpoints in clinical trials of chronic kidney disease

Abstract:

In March of 2018, the National Kidney Foundation, in collaboration with the US Food and Drug Administration and the European Medicines Agency, sponsored a workshop in which surrogate endpoints other than currently established event‐time endpoints for clinical trials in chronic kidney disease (CKD) were presented and discussed. One such endpoint is a slope‐based parameter describing the rate of decline in the estimated glomerular filtration rate (eGFR) over time. There are a number of challeng...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/sim.8282

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Role:
Author
ORCID:
0000-0002-7531-6160
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Publisher:
Wiley Publisher's website
Journal:
Statistics in Medicine Journal website
Volume:
38
Issue:
22
Pages:
4218-4239
Publication date:
2019-07-23
Acceptance date:
2019-05-29
DOI:
EISSN:
1097-0258
ISSN:
0277-6715
Pubs id:
pubs:1035881
UUID:
uuid:f23e1b05-6d8e-4634-9eb2-a5775f2dc619
Source identifiers:
1035881
Local pid:
pubs:1035881

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