Journal article
A failure of meiotic chromosome segregation in a fbh1Delta mutant correlates with persistent Rad51-DNA associations.
- Abstract:
- The F-box DNA helicase Fbh1 constrains homologous recombination in vegetative cells, most likely through an ability to displace the Rad51 recombinase from DNA. Here, we provide the first evidence that Fbh1 also serves a vital meiotic role in fission yeast to promote normal chromosome segregation. In the absence of Fbh1, chromosomes remain entangled or segregate unevenly during meiosis, and genetic and cytological data suggest that this results in part from a failure to efficiently dismantle Rad51 nucleofilaments that form during meiotic double-strand break repair.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 7.3MB, Terms of use)
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- Publisher copy:
- 10.1093/nar/gkq977
Authors
- Publisher:
- Oxford University Press
- Journal:
- Nucleic acids research More from this journal
- Volume:
- 39
- Issue:
- 5
- Pages:
- 1718-1731
- Publication date:
- 2011-03-01
- DOI:
- EISSN:
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1362-4962
- ISSN:
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0305-1048
- Language:
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English
- Keywords:
- Pubs id:
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pubs:107022
- UUID:
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uuid:f1b0d68f-cf6c-4644-bda0-790f8f688ab8
- Local pid:
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pubs:107022
- Source identifiers:
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107022
- Deposit date:
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2012-12-19
- ARK identifier:
Terms of use
- Copyright holder:
- Weili Sun, Alexander Lorenz, Fekret Osman and Matthew C Whitby
- Copyright date:
- 2011
- Notes:
- Copyright © 2010 Weili Sun, Alexander Lorenz, Fekret Osman and Matthew C. Whitby. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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