Thesis
Exploring the impact of patient-derived NMDAR NR1-specific IgG antibodies on the developing mouse striatum
- Abstract:
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Maternal antibodies targeting neuronal proteins, such as the NMDA receptor (NMDAR) and its NR1 subunit, can cross the foetal blood-brain barrier and disrupt neurodevelopment. Previous studies suggest that these NR1-targeting antibodies may be elevated in mothers of children with neurodevelopmental disorders, and animal models have shown that exposure to them during gestation leads to developmental abnormalities that persist into adulthood. The central hypothesis of this thesis is that early e...
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- Files:
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(Preview, Dissemination version, pdf, 17.0MB, Terms of use)
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Authors
Contributors
+ Ellender, T
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- ORCID:
- 0000-0001-9787-3307
+ Anthony, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- ORCID:
- 0000-0003-1380-6655
+ Minichiello, L
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Deposit date:
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2026-02-20
- ARK identifier:
Terms of use
- Copyright holder:
- Anežka D B Macey-Dare
- Copyright date:
- 2024
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