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Thesis

Modelling the impact of cyclic hypoxia on cell-cycle regulation in cancer cells

Abstract:

In vivo observations show that oxygen levels in tumours can fluctuate on fast timescales. As a result, cancer cells can be periodically exposed to pathologically low oxygen levels; a phenomenon known as cyclic hypoxia. Even though in vitro models of cyclic hypoxia exist, they fail to capture the complex and heterogeneous oxygenation dynamics of real tumours. Mathematical models can help to overcome current experimental limitations and, by doing so, offer new insights into the biol...

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Division:
MPLS
Department:
Mathematical Institute
Role:
Author

Contributors

Role:
Supervisor
ORCID:
0000-0003-1771-5910
Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0002-2335-3146
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Name:
Engineering and Physical Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Funding agency for:
Celora, G
Grant:
EP/L016044/1
Programme:
Centre for Doctoral Training in Systems Approaches to Biomedical Science
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
DOI:

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