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Thesis

Computational studies of talin-mediated integrin activation

Abstract:

Integrins are large heterodimeric (αβ) cell surface receptors that play a key role in the formation of focal adhesion complexes and are involved in various signal transduction pathways. They are ‘activated’ to a high affinity state by the formation of an intracellular complex between the membrane, the integrin β-subunit tail and talin, a process known as ‘inside-out activation’. The head domain of talin, a FERM domain homologue, plays a vital role in the formation of this complex. Recent ...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

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Supervisor
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Funding agency for:
Antreas C. Kalli
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:ed4652dd-af20-4550-8c45-2b5f9c443ff6
Local pid:
ora:7695

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