Thesis
Computational studies of talin-mediated integrin activation
- Abstract:
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Integrins are large heterodimeric (αβ) cell surface receptors that play a key role in the formation of focal adhesion complexes and are involved in various signal transduction pathways. They are ‘activated’ to a high affinity state by the formation of an intracellular complex between the membrane, the integrin β-subunit tail and talin, a process known as ‘inside-out activation’. The head domain of talin, a FERM domain homologue, plays a vital role in the formation of this complex. Recent ...
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Funding
Bibliographic Details
- Publication date:
- 2013
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:ed4652dd-af20-4550-8c45-2b5f9c443ff6
- Local pid:
- ora:7695
- Deposit date:
- 2014-02-03
Terms of use
- Copyright holder:
- Kalli, A
- Copyright date:
- 2013
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