Journal article
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
- Abstract:
-
The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF ≤ 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants1,2,3,4,5,6,7,8, as well as rare, population‐specific, coding variants9. Here we identify novel non‐coding genetic variants with large effects on BM...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 541.9KB, Terms of use)
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(Figures/images, zip, 4.9MB, Terms of use)
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(Supplementary materials, zip, 926.2KB, Terms of use)
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- Publisher copy:
- 10.1038/nature14878
Authors
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature More from this journal
- Volume:
- 526
- Issue:
- 7571
- Pages:
- 112-117
- Publication date:
- 2015-09-14
- Acceptance date:
- 2015-06-30
- DOI:
- EISSN:
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1476-4687
- ISSN:
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0028-0836
Item Description
- Language:
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English
- Pubs id:
-
pubs:571273
- UUID:
-
uuid:ebad5047-41db-45b7-977f-325a13d561b0
- Local pid:
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pubs:571273
- Source identifiers:
-
571273
- Deposit date:
-
2016-03-02
Terms of use
- Copyright holder:
- Zheng et al
- Copyright date:
- 2015
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Nature at: http://dx.doi.org/10.1038/nature14878
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