Oxford Thesis Collection

Thesis

Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods

Abstract:: Altered cellular metabolism, as a result of oncogenic mutations, has been observed in a range of cancer types. A detailed understanding of how cancers modify cellular metabolism, which includes changes to the genome, proteome and metabolome, is therefore integral for the development of effective and targeted therapeutic treatments.

Isocitrate dehydrogenase mutations lead to a change of enzyme function, which causes the production of high intracellular concentrations of 2 hydroxyg...
Expand abstract
Collapse abstract

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Walsby-Tickle, J. (2020). Investigating isocitrate dehydrogenase mutations in cancer using new metabolomics methods [PhD thesis]. University of Oxford.

MLA Style

Walsby-Tickle, J. Investigating Isocitrate Dehydrogenase Mutations in Cancer Using New Metabolomics Methods. 2020. University of Oxford, PhD thesis.

Chicago Style

Walsby-Tickle, J. 2020. “Investigating Isocitrate Dehydrogenase Mutations in Cancer Using New Metabolomics Methods.” PhD thesis, University of Oxford.
Print

Access Document

Files:: INVESTIGATING_ISOCITRATE_DEHYDROGENASE_MUTATIONS_IN_CANCER_USI...

(Preview, Version of record, pdf, 9.1MB, Terms of use)

Authors

+ Walsby-Tickle, J More by this author

Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Contributors

Role:: Supervisor
ORCID:: 0000-0003-4733-1205

+ Engineering and Physical Sciences Research Council More from this funder

Funder identifier:: http://dx.doi.org/10.13039/501100000266
Grant:: 1809885

DOI:: 10.5287/ora-pdrwqpwkx
Type of award:: DPhil
Level of award:: Doctoral
Awarding institution:: University of Oxford

Language:: English
Keywords:: LC-MS

Cancer

Metabolomics

IC-MS
Subjects:: Analysis

Mass spectrometry

Chemistry
Deposit date:: 2020-08-18
ARK identifier:: ark:/29072/ora_eb55ebc8ad5d403aaf9ab1f21ee21cc8

Terms of use

Copyright holder:: Walsby-Tickle, J

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP