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Thesis

Modulating the immune system by amino acid depletion - IDO and beyond

Abstract:

Amino acid availability plays an important role in modulating the activity of T-cells. One of the pathways employed by T-cells to sense nutrient levels is the “mammalian target of rapamycin” (mTOR) pathway that is inhibited in response to nutrient depletion. Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme along the tryptophan catabolising kynurenine pathway. T-cells are very sensitive to lack of this essential amino acid in their microenvironment and this confers st...

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Institution:
University of Oxford
Oxford college:
Merton College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of

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Role:
Supervisor
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Funding agency for:
Laura Vallius
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:eb1a1987-4121-4042-be82-2aafb67c9941
Local pid:
ora:11571

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