The role of elements binding CTCF and cohesin in directing tissue-specific enhancer activity

Thesis

Distal enhancer elements regulate the tissue-specific expression of their target genes via the establishment of physical interactions with the gene promoter. In mice, a cluster of five enhancers, jointly classified as a super-enhancer, specifically upregulate α-globin gene expression during erythroid differentiation. Aside from the Nprl3 gene, whose promoter is located inside this enhancer region, expression-levels of other genes within a short distance (<,50kb) of the...

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Authors: Hanssen, L

• DOI: 10.5287/ora-pdrpqvxdv
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: 4C; Gene regulation; Hi-C; Nuclear organisation; chromatin; Rad21; Cohesin; CTCF
• Subjects: Chromatin organisation; Gene regulation; Chromatin structure; CTCF