The effect of manipulating the expression of the NR2B subunit of the NMDA receptor on learning and memory

Thesis

Overexpression of the NR2B subunit of the NMDA receptor in the forebrain has been shown to improve learning and memory in mice (Tang et al 1999), which provides exciting implications for the enhancement of human cognition. However, it was first essential to establish replicability, and since the Tang et al (1999) study used only male mice we wished to investigate possible sex differences.

On the hidden platform watermaze, we found a trend for male NR2BOE mice to learn the task more q...

Expand abstract

Authors: Hoon, A

• Publication date: 2011
• DOI: 10.5287/ora-8jqabbxab
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: NR2B; learning; mice; NMDA receptor; neuroscience; memory
• Subjects: Behavioural Neuroscience; Membrane proteins; Memory; Neurogenetics; Genetics (life sciences); Neurology; Experimental psychology; Cognition; Transgenics; Physiology; Cognitive Neuroscience; Molecular genetics; Neuroscience; Learning