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The effect of manipulating the expression of the NR2B subunit of the NMDA receptor on learning and memory

Abstract:

Overexpression of the NR2B subunit of the NMDA receptor in the forebrain has been shown to improve learning and memory in mice (Tang et al 1999), which provides exciting implications for the enhancement of human cognition. However, it was first essential to establish replicability, and since the Tang et al (1999) study used only male mice we wished to investigate possible sex differences.

On the hidden platform watermaze, we found a trend for male NR2BOE mice to learn the task more q...

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Institution:
University of Oxford
Oxford college:
Merton College
Department:
Medical Sciences Division - Psychiatry

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Role:
Supervisor
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Funding agency for:
Amy Hoon
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:eae324a3-873f-4b50-9bcc-8c43b72866a3
Local pid:
ora:6217

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