Striatal GABA transporter regulation of dopamine release and dysfunction in Parkinsonian models

Thesis

Mesostriatal dopamine (DA) signalling plays a central role in the functions of the basal ganglia, facilitating behavioural processes such as action selection and reinforcement learning. Consequently, dysregulation of DA signalling is implicated in a diversity of neurological and psychiatric disorders including Parkinson’s disease and addictions. It is increasingly appreciated that DA output from DA axons in striatum is subject to major influences besides action potentials generated at the ...

Expand abstract

Authors: Roberts, BM

• DOI: 10.5287/ora-y5rep10da
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: voltammetry; GABA receptor; Parkinson's disease; striatum; neuron-glia interactions; GAT; electrophysiology; GABA transporter; release probability; optogenetics; co-release; astrocytes; tonic inhibition; dopamine
• Subjects: Neurosciences