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Thesis

Chemical biology of GPR84 – a pro-inflammatory protein

Abstract:

Heptahelical transmembrane G protein-coupled receptors (GPCRs) represent crucial targets in medical research. G protein-coupled receptor 84 (GPR84) is a GPCR associated with cancer, inflammatory, and fibrotic diseases. The activation of GPR84 with agonists has shown potential in enhancing bacteria and antibody-dependent cancer cell phagocytosis in macrophages. The objective of this thesis was to optimise the metabolically labile G-protein biased agonist DL-175 into a suitable in vivo

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Supervisor

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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