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Thesis

Investigating protein-protein interactions of the Bloom Syndrome complex

Abstract:

Bloom Syndrome is a rare recessive chromosomal instability disorder, caused by loss-of-function mutations in the BLM helicase tumour suppressor. Patients develop a variety of developmental defects and have an increased predisposition to all cancers.

BLM interacts with TOP3A, RMI1 and RMI2 to form the BTR complex, which functions to promote the restart of stalled forks and the dissolution of double Holliday junctions during homologous recombination repair to the prevent the format...

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Division:
MSD
Department:
Oncology
Role:
Author

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Role:
Supervisor
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Name:
The Aziz Foundation
Programme:
The Aziz Foundation Masters Scholarship Programme
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
Language:
English
Keywords:
Deposit date:
2021-10-15

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