Thesis
Investigating the substrate selectivity and the inhibitor of the human KDM7 sub-family of JmjC histone lysine demethylases
- Abstract:
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The regulation of gene expression by the post-translational modifications (PTMs) of histone tails is important in eukaryotic cell biology and of current medical interest. Specific PTMs to histone tails, including acetylation, phosphorylation and methylation, can either promote or inhibit transcription of specific sets of genes. Histone methylation was once thought to be irreversible but is no known to be dynamic. The extent of Ne-methyl lysine- and arginine-methylation is regulated by ...
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(Preview, Dissemination version, pdf, 14.4MB, Terms of use)
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Authors
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- UUID:
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uuid:e936321a-f5d0-4356-b722-9f8cad92ae27
- Deposit date:
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2019-11-27
- ARK identifier:
Terms of use
- Copyright holder:
- Zhang, Y
- Copyright date:
- 2019
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