Thesis icon

Thesis

Investigating the substrate selectivity and the inhibitor of the human KDM7 sub-family of JmjC histone lysine demethylases

Abstract:

The regulation of gene expression by the post-translational modifications (PTMs) of histone tails is important in eukaryotic cell biology and of current medical interest. Specific PTMs to histone tails, including acetylation, phosphorylation and methylation, can either promote or inhibit transcription of specific sets of genes. Histone methylation was once thought to be irreversible but is no known to be dynamic. The extent of Ne-methyl lysine- and arginine-methylation is regulated by ...

Expand abstract

Actions


Authors


More by this author
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:e936321a-f5d0-4356-b722-9f8cad92ae27
Deposit date:
2019-11-27

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP